![]() Diagnosis is by CT scan, pulmonary function tests or lung biopsy. The underlying mechanism involves inflammation that results in scar tissue formation. Symptoms may not occur until two to eight weeks following toxic exposure or infection. Ĭauses include breathing in toxic fumes, respiratory infections, connective tissue disorder or complications following a bone marrow or heart-lung transplant. It is not related to cryptogenic organizing pneumonia, previously known as bronchiolitis obliterans organizing pneumonia. These symptoms generally get worse over weeks to months. Symptoms include a dry cough, shortness of breath, wheezing and feeling tired. Toxic fumes, respiratory infections, connective tissue disorder, following a bone marrow or heart-lung transplant ĬT scan, pulmonary function tests, lung biopsy Ĭorticosteroids, immunosuppressive medication, lung transplant īronchiolitis obliterans ( BO), also known as obliterative bronchiolitis, constrictive bronchiolitis and popcorn lung, is a disease that results in obstruction of the smallest airways of the lungs ( bronchioles) due to inflammation. High resolution CT scan showing bronchiolitis obliterans with mosaic attenuation, bronchiectasis, air trapping and bronchial thickening ĭry cough, shortness of breath, wheezing, feeling tired None of the patients with a subacute clinical course required mechanical ventilation.Medical condition Bronchiolitis obliterans Ĭonstrictive bronchiolitis, Obliterative bronchiolitis, Popcorn lung The need for mechanical ventilation was the only parameter that correlated with prognosis. The overall mortality rate is similar to DAD and therefore may represent a histologic variant however, AFOP appears to have 2 distinct patterns of disease progression and outcome. Similar to these patterns of acute lung injury, the AFOP pattern can occur in an idiopathic setting or with a spectrum of clinical associations. Histologic analysis and initial symptoms did not correlate with eventual outcome, but 5 of the 5 patients who required mechanical ventilation died (P =.007).Īcute fibrinous and organizing pneumonia is a histologic pattern associated with a clinical picture of acute lung injury that differs from the classic histologic patterns of DAD, BOOP, or EP. Follow-up revealed 2 clinical patterns of disease progression: a fulminate illness with rapid progression to death (n = 9 mean survival, 0.1 year) and a more subacute illness, with recovery (n = 8). Six patients had no identifiable origin or association. (1), lymphoma (1), hairspray (1), construction work (1), coal mining (1), and zoological work (1). Associations believed to be clinically related to the lung disease included definitive or probable collagen vascular disease (3), amiodarone (1), sputum culture positive for Haemophilus influenza (1), lung culture positive for Acinetobacter sp. Seventeen patients (10 men, 7 women) with a mean age of 62 years (range, 33-78 years) had acute-onset symptoms of dyspnea (11), fever (6), cough (3), and hemoptysis (2). Statistical analysis was performed using Kaplan-Meier and chi(2) analysis. To determine the clinical behavior of patients with this histologic finding, clinical and radiographic information and follow-up information were obtained. Cases with histologic patterns of classic DAD, BOOP, abscess formation, or eosinophilic pneumonia were excluded. Varying amounts of organizing pneumonia, type 2 pneumocyte hyperplasia, edema, acute and chronic inflammation, and interstitial widening were seen. Open lung biopsy specimens and autopsy specimens were selected from the consultation files of the Armed Forces Institute of Pathology, which showed a dominant histologic pattern of intra-alveolar fibrin and organizing pneumonia. To investigate the clinical significance of the AFOP histologic pattern and to explore its possible relationship to other disorders, including DAD and BOOP. We have recognized acute fibrinous and organizing pneumonia (AFOP) as a histologic pattern, which also occurs in this clinical setting but does not meet the classic histologic criteria for DAD, BOOP, or EP and may represent an underreported variant. The histologic patterns of diffuse alveolar damage (DAD), bronchiolitis obliterans with organizing pneumonia (BOOP), and eosinophilic pneumonia (EP) are well-recognized histologic patterns of lung injury associated with an acute or subacute clinical presentation.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |